|
Urinary Bladder Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
A centrally acting EP3 receptor antagonist may be useful in the control of detrusor overactivity and/or pain associated with bladder disorders.
|
18632791 |
2008 |
|
Tumor Cell Invasion
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
However, the functions and the mechanisms of those splice variants of EP3 receptors in promoting liver cancer cell growth and invasion remain to be elucidated.
|
26058972 |
2015 |
|
Toxic Epidermal Necrolysis
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
In a previous genome-wide association study of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) patients we reported the association between SJS/TEN and the prostaglandin E receptor 3 (PTGER3) gene, and that its protein PGE<sub>2</sub> receptor 3 (EP3) was markedly downregulated in the conjunctival epithelium of SJS/TEN patients.
|
31000507 |
2019 |
|
Toxic Epidermal Necrolysis
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphism association analysis showed that the Toll-like receptor 3 (TLR3), prostaglandin-E receptor 3 (PTGER3), and IKZF1 gene were significantly associated with CM-SJS/TEN with SOC and that they could regulate mucocutaneous inflammation including that of the ocular surface.
|
30481825 |
2018 |
|
Toxic Epidermal Necrolysis
|
0.320 |
Biomarker
|
disease |
CTD_human |
In the current study we investigated the expression of EP3 protein in the conjunctiva of patients with various ocular surface diseases such as SJS/TEN, chemical eye burns, Mooren's ulcers, and ocular cicatricial pemphigoid (OCP).
|
21966456 |
2011 |
|
Thrombus
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Vascular wall-produced prostaglandin E2 exacerbates arterial thrombosis and atherothrombosis through platelet EP3 receptors.
|
17242161 |
2007 |
|
Thrombosis
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Vascular wall-produced prostaglandin E2 exacerbates arterial thrombosis and atherothrombosis through platelet EP3 receptors.
|
17242161 |
2007 |
|
Stomach Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Hypermethylation of TPEF (a growth inhibitor), PTGER3 (a prostaglandin receptor isoform), and MINT31 (a promoter locus regulating calcium channels that is involved in p53 mutation) discriminated NIN and GC from normal mucosa, suggesting an early role as initiating events, whereas hypermethylation at ARGHAP20 developed with the progression from NIN to GC.
|
22179688 |
2012 |
|
Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
In a previous genome-wide association study of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) patients we reported the association between SJS/TEN and the prostaglandin E receptor 3 (PTGER3) gene, and that its protein PGE<sub>2</sub> receptor 3 (EP3) was markedly downregulated in the conjunctival epithelium of SJS/TEN patients.
|
31000507 |
2019 |
|
Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum
|
0.310 |
Biomarker
|
disease |
CTD_human |
Prostaglandin E receptor subtype EP3 expression in human conjunctival epithelium and its changes in various ocular surface disorders.
|
21966456 |
2011 |
|
Stevens-Johnson Syndrome
|
0.310 |
Biomarker
|
disease |
CTD_human |
In our earlier genome-wide association study on Stevens-Johnson Syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), we found that in Japanese patients with these severe ocular surface complications there was an association with prostaglandin E receptor 3 (EP3) gene (PTGER3) polymorphisms.
|
21966456 |
2011 |
|
Stevens-Johnson Syndrome
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
Association between prostaglandin E receptor 3 polymorphisms and Stevens-Johnson syndrome identified by means of a genome-wide association study.
|
20947153 |
2010 |
|
Squamous cell carcinoma of the head and neck
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results presented here show that HNSCC tumoral lesions and their derived cell lines constitutively express COX-2 and the EP1, EP2 and EP3 receptors for PGE2.
|
20951077 |
2010 |
|
Sporadic Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our study evaluates EP3 receptor expression in sporadic breast cancer and its association with clinicopathological parameters, progression-free and overall survival.
|
29661238 |
2018 |
|
Sleep Apnea, Obstructive
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Among 2,904 individuals of European ancestry, rs1409986 in the prostaglandin E2 receptor (PTGER3) gene was significantly associated with OSA.
|
23155414 |
2012 |
|
Secondary Neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
Here we tested whether the EP3 receptor has a critical role in tumor metastasis.
|
19799610 |
2009 |
|
Sclerocystic Ovaries
|
0.300 |
Biomarker
|
disease |
CTD_human |
Progesterone resistance in PCOS endometrium: a microarray analysis in clomiphene citrate-treated and artificial menstrual cycles.
|
21411543 |
2011 |
|
Schwartz-Jampel Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphism association analysis showed that the Toll-like receptor 3 (TLR3), prostaglandin-E receptor 3 (PTGER3), and IKZF1 gene were significantly associated with CM-SJS/TEN with SOC and that they could regulate mucocutaneous inflammation including that of the ocular surface.
|
30481825 |
2018 |
|
Schizophrenia
|
0.310 |
Biomarker
|
disease |
PSYGENET |
We found that levels of prostaglandin-endoperoxide synthase 1 (PTGS1; aka COX-1) and prostaglandin-endoperoxide receptor 3 (PTGER3) mRNA are increased, and levels of prostaglandin-endoperoxide synthase 2 (PTGS2; aka COX-2) mRNA are decreased, in older subjects with schizophrenia (> 40years of age) compared to matched normal controls or younger subjects with schizophrenia (< 40years of age).
|
22397921 |
2012 |
|
Schizophrenia
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
We found that levels of prostaglandin-endoperoxide synthase 1 (PTGS1; aka COX-1) and prostaglandin-endoperoxide receptor 3 (PTGER3) mRNA are increased, and levels of prostaglandin-endoperoxide synthase 2 (PTGS2; aka COX-2) mRNA are decreased, in older subjects with schizophrenia (> 40years of age) compared to matched normal controls or younger subjects with schizophrenia (< 40years of age).
|
22397921 |
2012 |
|
Prostate carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Significance of divergent expression of prostaglandin EP4 and EP3 receptors in human prostate cancer.
|
23364535 |
2013 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
An association between higher tumoral expression of PTGER3 and shorter patient survival in the ovarian cancer dataset of The Cancer Genome Atlas prompted investigation of the antitumor effects of PTGER3 downmodulation.
|
30655206 |
2019 |
|
Primary malignant neoplasm
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Almost all tested plants upregulated the expression of the prostaglandin E receptor 3 gene (PTGER3) suggesting their potential benefits in the treatment of cancer.
|
30987861 |
2019 |
|
Postoperative cognitive dysfunction
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
This study showed that PGE2-EP3 signaling pathway was involved in the progression of POCD and identified EP3 receptor as a promising treatment target.
|
29488342 |
2018 |
|
polyps
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
We detected association signals in the genes PGE receptor 3 (PTGER3) and 15-hydroxyprostaglandin dehydrogenase (HPGD), both strong biologic candidates for influence on polyp risk.
|
22551900 |
2012 |